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Microwave-Assisted Improved Synthesis of Pyrrolo[2,3,4-kl]acridine and Dihydropyrrolo[2,3,4-kl]acridine Derivatives Catalyzed by Silica Sulfuric Acid
oleh: Chengpao Cao, Changliang Xu, Wei Lin, Xuemei Li, Minghua Hu, Juxian Wang, Zhibin Huang, Daqing Shi, Yucheng Wang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2013-01-01 |
Deskripsi
An improved synthesis of multifunctionalized pyrrolo[2,3,4-kl]acridine derivatives with different substituted patterns using silica sulfuric acid (SSA) as a heterogeneous catalyst under microwave irradiation conditions was developed. The reaction could be conducted by using readily available and inexpensive substrates within short periods of 12–15 min. under microwave irradiation. Compared with the conventional methods, the remarkable advantages of this method are milder reaction conditions, operational simplicity, higher yields, short reaction times, and an environmentally friendly procedure.