Access to highly substituted oxazoles by the reaction of α-azidochalcone with potassium thiocyanate
oleh: Mysore Bhyrappa Harisha, Pandi Dhanalakshmi, Rajendran Suresh, Raju Ranjith Kumar, Shanmugam Muthusubramanian
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2020-08-01 |
Deskripsi
The reactivity of α-azidochalcones has been explored for the preparation of highly substituted oxazoles via a 2H-azirine intermediate. The azidochalcones, when treated with potassium thiocyanate in the presence of potassium persulfate, lead to 2,4,5-trisubstituted oxazoles in good yields. Incidentally, 2-aminothiazoles are the products when ferric nitrate is employed instead of persulfate in the above reaction.