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Conor Kelly examines social inequities and, by strongly advocating for social justice, frames ethical priorities. In particular, he invites to focus not only on what we do not know about cancer (e.g., in terms of scientific understanding and medical know-how), but also on what we already know about cancer regarding its toll on human beings and societies, as well the continuing and even increasing inequities in cancer care across the planet. Hence, new ethical priorities for the ongoing global journey with cancer require a greater emphasis on combatting the disparities that shape peoples’ experiences of cancer, expand access to the cancer treatments that are known to work and work well, and increase access to palliative care for patients with cancer.