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Objectives: This study aims to investigate the effect of ketamine on angiogenesis. Materials and methods: Between June 2021 and August 2021, chorioallantoic membrane (CAM) assay cell viability assay protocols and cell viability assay protocols were performed to investigate angiogenesis. While in vivo angiogenic property of ketamine was studied in the chick CAM model, its effect on in vitro cell proliferation was evaluated in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Results: A significant anti-angiogenic effect of ketamine was observed in chick CAM in the in vivo setting, compared to the control group (p [Turk J Vasc Surg 2022; 31(2.000): 67-71]