The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi
oleh: Louisa L. Y. Chan, Danielle E. Anderson, Hong Sheng Cheng, Fransiskus Xaverius Ivan, Si Chen, Adrian E. Z. Kang, Randy Foo, Akshamal M. Gamage, Pei Yee Tiew, Mariko Siyue Koh, Ken Cheah Hooi Lee, Kristy Nichol, Prabuddha S. Pathinayake, Yik Lung Chan, Tsin Wen Yeo, Brian G. Oliver, Peter A. B. Wark, Linbo Liu, Nguan Soon Tan, Lin-Fa Wang, Sanjay H. Chotirmall
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-12-01 |
Deskripsi
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory respiratory disease characterized by airflow limitation and infective exacerbations. Here, Chan et al. report the generation of nasopharyngeal and bronchial COPD organoids derived from adult stem cells and employ them in the study of host-pathogen interactions, including SARS-CoV-2 and Pseudomonas aeruginosa.