Accelerating functional gene discovery in osteoarthritis
oleh: Natalie C. Butterfield, Katherine F. Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S. Mannan, Anne-Tounsia Adoum, Victoria D. Leitch, John G. Logan, Julian A. Waung, Elena Ghirardello, Lorraine Southam, Scott E. Youlten, J. Mark Wilkinson, Elizabeth A. McAninch, Valerie E. Vancollie, Fiona Kussy, Jacqueline K. White, Christopher J. Lelliott, David J. Adams, Richard Jacques, Antonio C. Bianco, Alan Boyde, Eleftheria Zeggini, Peter I. Croucher, Graham R. Williams, J. H. Duncan Bassett
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
Osteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and after single gene deletion or point mutation.