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[Introduction] In the near future, the possibility of launching inland nuclear power is less likely, so China′s nuclear power construction will be mainly based on coastal projects. As shoreline resources become increasingly scarce, it is increasingly difficult for coastal nuclear power plants to choose sites. Therefore, it is necessary to broaden the thinking and select sites scientifically. [Method] This paper recommended to focus on the coastal sub-region, adoptedd secondary circulation cooling technical scheme, and demonstrated the conditions of seismic geology, emergency evacuation and environmental protection, so as to make better selection of nuclear power plant site. [Result] The actual situation of a nuclear power project in western Guangdong shows that the new ideas and methods are helpful to optimize the site selection and scientific decision-making. [Conclusion] The research of this paper is of great reference to the site selection of subsequent nuclear power plants, and it is of great significance to make nuclear power layout more scientific.