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<p><strong>Introduction:</strong> Empathy is the adequate understanding towards the patient; it is considered the central axis of the doctor-patient relationship and is a vital component for high-quality health care.</p><p><strong>Objective:</strong> To determine the levels of empathy towards the patient and their association with family functionality, stress, academic performance and sociodemographic and academic factors of medical students.</p><p><strong>Material and Methods:</strong> An observational, descriptive cross-sectional study was conducted. The study population included 130 medical students (between 3rd-year and 6-th year) who fulfilled the inclusion and exclusion criteria. The independent variables were family functionality, stress and academic performance. A questionnaire and the Jefferson Scale of Empathy Version S were applied. For the analysis, the Shapiro-Wilk test was used for testing the assumption of normality, the Student t Test and Anova test were used to establish the relationship between variables. Statistical significance of p &lt;0.05 was considered.</p><p><strong>Results:</strong> The average global empathy was 106.08 ± 18.29 points. Statistically significant differences were found between global empathy and sex (p = 0.03), year of studies (p = 0.00), and family functionality (p = 0.04).</p><p><strong>Conclusions:</strong> The level of family functioning is associated with empathy.  Moreover, it was also found that women were more empathic than men and higher academic years were associated with a lower level of empathy towards the patient.</p>