Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi
oleh: Simone Früholz, Florian Fäßler, Üner Kolukisaoglu, Peter Pimpl
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-02-01 |
Deskripsi
Vacuolar sorting receptors (VSRs) are suggested to efficiently transport hydrolases by continuous cycling. Here, the authors use a nanobody-epitope interaction-based labeling approach to trace VSR recycling from the TGN/EE to the cis-Golgi and reveal ligand reloading of recycled VSRs.