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EXD2: A new regulator of mitochondrial translation and potential target for cancer therapy
oleh: Travis H. Stracker
Format: | Article |
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Diterbitkan: | Taylor & Francis Group 2018-05-01 |
Deskripsi
In recent work we identified Exonuclease 3′−5′ domain-containing protein 2 (EXD2) as an RNase required for efficient mitochondrial translation. Here I describe in brief the cellular phenotypes caused by EXD2 deficiency and make the case that EXD2 inhibitors could be valuable agents for cancer therapy.