Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase

oleh: Allison Judge, Liya Hu, Banumathi Sankaran, Justin Van Riper, B. V. Venkataram Prasad, Timothy Palzkill

Format: Article
Diterbitkan: Nature Portfolio 2023-01-01

Deskripsi

Structural analysis, antibiotic selection, and deep sequencing of CTX-M-14 mutants identify residues required for β-lactamase activity.