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The study was conducted in adult albino rats of either sex weighing 150-200 gm to assess the anti-ulcer property of Withanra sornnifera (Amukkiram) roots given orally at different dose levels and frequency in aspirin induced gastric ulcers in comparison with Famotidine. All experimental groups under W. sornnifera root significantly reduced the ulcer index when compared with aspirin treated control [CG (A)]. Alcoholic extracts of Withania sonrrrifera produced adose-dependent increase in anti-ulcer activity while healing effect produced W. sornnifera root powder are not dose-dependent.