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The study was carried out randomly in 20 patients of ASA grade I and II of either sex, between the ages of 25 and 65 years scheduled for laparoscopic cholecystectomy. We studied the effect of intraperitoneal CO 2 insufflation with head up position, on RR interval, QT interval, QTc interval, QT Dispersion, QTc Dispersion using computerized measurement with the help of 12 lead ECG. The RR interval did not change significantly during the study but there was statistically significant increase in QT interval, QTD and QTcD.