RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity
oleh: Sumin Feng, Sai Ma, Kejiao Li, Shengxian Gao, Shaokai Ning, Jinfeng Shang, Ruiyuan Guo, Yingying Chen, Britny Blumenfeld, Itamar Simon, Qing Li, Rong Guo, Dongyi Xu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-02-01 |
Deskripsi
The 53BP1-RIF1 pathway is important for DNA repair. Here, the authors identified the histone chaperone ASF1, which functions as a suppressor of DNA end resection through changing high-order chromatin structure, as a partner of RIF1. This finding links DNA repair and dynamic changes of high-order chromatin structure.