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China is experiencing severe PM_2.5 (fine particles with a diameter of 2.5 μg or smaller) pollution problem. Little is known, however, about how the increasing concentration trend is spatially distributed, nor whether there are some areas that experience a stable or decreasing concentration trend. Managers and policymakers require such information to make strategic decisions and monitor progress towards management objectives. Here, we present a pixel-based linear trend analysis of annual PM_2.5 concentration variation in China during the period 1999−2016, and our results provide guidance about where to prioritize management efforts and affirm the importance of controlling coal energy consumption. We show that 87.9% of the whole China area had an increasing trend. The drastic increasing trends of PM_2.5 concentration during the last 18 years in the Beijing−Tianjin−Hebei region, Shandong province, and the Three Northeastern Provinces are discussed. Furthermore, by exploring regional PM_2.5 pollution, we find that Tarim Basin endures a high PM_2.5 concentration, and this should have some relationship with oil exploration. The relationship between PM_2.5 pollution and energy consumption is also discussed. Not only energy structure reconstruction should be repeatedly emphasized, the amount of coal burned should be strictly controlled.