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Key messages 1. The JMCN has steadily and substantially grown for more than 2 decades and continues to significantly influence the global Immunology community. 2. In addition to compiling an extensive global patient database, the expanding JMCN acts as a unique and critical resource, increasing awareness of PIs, educating physicians and patients, and facilitating diagnosis via expertise and genetic sequencing, as well as treatment. 3. The JMCN provides a platform to optimize research advances, earliest diagnosis, enhanced treatments, and implement standard-of-care and best practices through maximized connectivity, resulting in a better quality of life and improved outcomes for patients with PI.