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This review mainly includes the following contents: 1) The multilevel of spatial topological structure of the fluid flow pathway is viewed from the transverse perspective (cross section), including perivascular space, basement membranes, tunica adventitia and perivascular connective tissue. And the diverse phenomenon of fluid flow at all levels of vascular structure is discussed; 2) The interstitial fluid flow in vascular trees throughout the whole body is viewed from the longitudinal perspective;3) The similarities and differences between domestic and foreign research results are compared;4) The potential physiological function of the interstitial fluid flow along the circulatory system is prospected.