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Background: Wrist pain is one of common and disabling condition in working population; there are various risk factors that enhance the prevalence of wrist pain in different working class. Objectives of Study: This study is intended to determine the risk factors for wrist pain associated with nature of work. Methodology: The descriptive cross sectional study design was used to determine the risk factors. A sample of 196 patients was recruited through purposive sampling from 1st June -31st December 2013 from different hospitals of Rawalpindi and Islamabad. The detail demographic information was taken from diagnosed cases of wrist pain along with risk factors. Results: The results showed that the mean age of patients' were32±6 with age bracket of 21- 30years. The prevalence of wrist pain 59(29%) in house wives and office workers were 51(26%). The most common factor is multiple activities 62(31%), type writing 60(30%) and cooking and washing 41(21%). Conclusions: The findings of the current study highlighted that housewives are more prone to wrist pain, and occupations that require repetitive work is the most common risk factor. Key Words: Wrist pain, risk factors, female gender, occupation, workload