Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections
oleh: Hattie Chung, Christina Merakou, Matthew M. Schaefers, Kelly B. Flett, Sarah Martini, Roger Lu, Jennifer A. Blumenthal, Shanice S. Webster, Ashley R. Cross, Roy Al Ahmar, Erin Halpin, Michelle Anderson, Nicholas S. Moore, Eric C. Snesrud, Hongwei D. Yu, Joanna B. Goldberg, George A. O’Toole, Patrick McGann, Jason A. Stam, Mary Hinkle, Alexander J. McAdam, Roy Kishony, Gregory P. Priebe
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-03-01 |
Deskripsi
It remains unclear how rapid antibiotic switching affects the evolution of antibiotic resistance in individual patients. Here, Chung et al. combine short- and long-read sequencing and resistance phenotyping of 420 serial isolates of Pseudomonas aeruginosa collected from the onset of respiratory infection, and show that rare resistance mutations can increase by nearly 40-fold over 5–12 days in response to antibiotic changes, while mutations conferring resistance to antibiotics not administered diminish and even go to extinction.