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<p class="abstract"><strong>Abstract</strong></p> <p class="abstract"><strong>&nbsp;&nbsp; INTRODUCTION: </strong>It has been demonstrated in recent studies that abnormal levels of adipocytokines may contribute to insulin resistance and type 2 diabetes. The aim of the present study was to compare serum leptin and adiponectin levels in controlled and non-controlled type 2 diabetes.&nbsp;&nbsp;&nbsp;</p> <p class="abstract">&nbsp;&nbsp; <strong>METHODS:</strong> 117 patients with controlled and non-controlled type 2 diabetes were studied. Patient, were divided into two groups based on their serum HbA1c level; there were 62 patients in the controlled group (6 %&lt; HbA1c&le; 8%) and 55 patients in uncontrolled group (HbA1c&gt;8%). Parameters like age, sex, duration of diabetes and biochemical indicators such as fasting blood sugar, HbA1c, insulin resistance, leptin and adiponectin were determined.</p> <p class="abstract"><strong>&nbsp;&nbsp; RESULTS:</strong> Higher leptin and lower adiponectin levels were observed in non-controlled type 2 diabetes. The levels of fasting blood sugar and insulin resistance were significantly higher in the non-controlled group (P&lt;0.05).</p> <p class="abstract"><strong>&nbsp;&nbsp; CONCLUSION:</strong> Leptin and adiponectin may play an important role in the regulation of insulin sensitivity and control of type 2 diabetes.</p> <p class="abstract">&nbsp;</p><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td width="35" height="12">&nbsp;</td></tr> <tr><td>&nbsp;</td> <td>&nbsp;</td></tr></tbody></table><p class="abstract">&nbsp;</p> <br /> <p class="abstract"><strong>Keywords:</strong> Type 2 Diabetes, Insulin resistance, Leptin, Adiponectin.</p>