Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages
oleh: Yuxian Guo, Yaru Liu, Shihao Zhao, Wangting Xu, Yiqing Li, Pengwei Zhao, Di Wang, Hongqiang Cheng, Yuehai Ke, Xue Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-12-01 |
Deskripsi
Redox-dependent regulation plays a key role in the pathogenesis of acute lung injury, but its mechanism is unclear. Here the authors show Grx1-regulated S-glutathionylation of FABP5 controls macrophage inflammation and alleviates acute lung injury.