Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance

oleh: Yan-Ting Chen, Qi-Yuan Yang, Yun Hu, Xiang-Dong Liu, Jeanene M. de Avila, Mei-Jun Zhu, Peter W. Nathanielsz, Min Du

Format: Article
Diterbitkan: Nature Portfolio 2021-11-01

Deskripsi

Maternal obesity predisposes offspring to obesity and metabolic disorders through incompletely understood mechanisms. Here the authors report that Dio3os is an imprinted long-coding RNA that modulates brown adipose tissue development and obesity resistance in the offspring.