TMEM16 scramblases thin the membrane to enable lipid scrambling
oleh: Maria E. Falzone, Zhang Feng, Omar E. Alvarenga, Yangang Pan, ByoungCheol Lee, Xiaolu Cheng, Eva Fortea, Simon Scheuring, Alessio Accardi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
Lipid scrambling is required for many cellular processes but the lipid-protein interactions that occur during transport are unknown. Using cryoEM and biochemical assays the authors show that membrane thinning is critical for lipid flipping.