Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance
oleh: Yu-San Huoh, Bin Wu, Sehoon Park, Darren Yang, Kushagra Bansal, Emily Greenwald, Wesley P. Wong, Diane Mathis, Sun Hur
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-04-01 |
Deskripsi
The transcription factor Aire mediates tissue-specific antigen expression in the thymus for T cell central tolerance induction. Here the authors show that Aire, via its CARD domain, forms multimers that can misdirect Aire to PML bodies leading to the loss of Aire transcriptional activity and induction of autoimmunity.