Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract
oleh: Shahzada Khan, Irene Lew, Frank Wu, Linda Fritts, Krystal A. Fontaine, Sakshi Tomar, Martin Trapecar, Hesham M. Shehata, Melanie Ott, Christopher J. Miller, Shomyseh Sanjabi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-09-01 |
Deskripsi
Here, Khan et al. show that enhanced Zika virus replication in the lower female reproductive tract of mice and macaques associates with low expression of RNA sensing pattern recognition receptors, while IFNAR signaling may be critical in preventing viral dissemination to distal tissues.