A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
oleh: Michael J. Texada, Anne F. Jørgensen, Christian F. Christensen, Takashi Koyama, Alina Malita, Daniel K. Smith, Dylan F. M. Marple, E. Thomas Danielsen, Sine K. Petersen, Jakob L. Hansen, Kenneth A. Halberg, Kim F. Rewitz
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-04-01 |
Deskripsi
The mechanisms by which organisms adapt their growth according to the availability of oxygen are incompletely understood. Here the authors identify the D rosophila fat body as a tissue regulating growth in response to oxygen sensing via a mechanism involving Hph inhibition, HIF1-a activation and insulin secretion.