Structural organization of erythrocyte membrane microdomains and their relation with malaria susceptibility
oleh: Anna Olivieri, Rebecca S. Lee, Federica Fratini, Cyrianne Keutcha, Mudit Chaand, Valentina Mangano, Francesco Celani, Stefania Mochi, Cecilia Birago, Silvio Paone, Felicia Grasso, Valentina Tirelli, Mario Falchi, Estela Shabani, Stefania Bertoncini, Bienvenu Sodiomon Sirima, Elisabetta Pizzi, David Modiano, Manoj T. Duraisingh, Marta Ponzi
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-12-01 |
Deskripsi
Olivieri et al. exploit floating properties of microdomain-associated proteins to investigate host proteins important for Plasmodium falciparum erythrocyte invasion. Using proteomic and bioinformatic approaches, they analyze clusters of protein abundance profiles from detergent resistant membranes (DRMs) of erythrocytes and identify a host protein, ART4, important for P. falciparum invasion into RBCs.