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The Functional Resonance Analysis Method (FRAM) is a novel research methodology that uses qualitative data collection methods to map and model complex healthcare processes by identifying and depicting the cumulative activities required to produce an outcome. The FRAM aims to identify the variability that can emerge in a process when healthcare activities are performed under dynamic conditions. With this knowledge, health care system design, safety, and quality improvement recommendations can be developed with a greater understanding of everyday process functionality. Researchers interested in using the FRAM require both an understanding of the methodology itself, as well as an understanding of how to effectively plan and conduct qualitative research. The purpose of this paper is to provide practical guidance to researchers on planning and operationalizing qualitative data collection and analysis methods to inform the building of a FRAM model. A combination of literature and practical experience will be used to examine and suggest appropriate ways for researchers to carry out this work.