Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy
oleh: Matteo Castelli, Andreina Baj, Elena Criscuolo, Roberto Ferrarese, Roberta A. Diotti, Michela Sampaolo, Federica Novazzi, Daniela Dalla Gasperina, Daniele Focosi, Davide Ferrari, Massimo Locatelli, Massimo Clementi, Nicola Clementi, Fabrizio Maggi, Nicasio Mancini
| Format: | Article |
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| Diterbitkan: | MDPI AG 2021-07-01 |
Deskripsi
SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.