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Oral cancer is one of the most common cancers in the developing world with high mortality rate despite the recent advances in diagnosis and treatment. The major reason for low survival rate is late diagnosis. Salivary diagnostics is an emerging field along with the application of genomics aiding in the early detection of oral cancer. These genomic alphabets of saliva may serve as a timely, cost effective, noninvasive diagnostic medium. This article aims to discuss the role of genomic alphabets of saliva in the diagnosis of oral cancer.