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Abstract. Rationale:. Coronavirus disease 2019 (COVID-19) is a systemic disease with major clinical manifestations in the respiratory system. However, thyroid involvement has also been reported. We present a case of hypothyroidism with ventricular tachycardia following diagnosis with COVID-19. Patient concerns:. A 77-year-old man was admitted to the isolation ward due to COVID-19. After respiratory support and medical treatment, the patient was successfully weaned off the ventilator. However, an episode of short-run ventricular tachycardia was detected, and primary hypothyroidism was also diagnosed. Diagnosis:. Ventricular tachycardia was detected by electrocardiography. Interventions:. Intravenous amiodarone administration and oral levothyroxine replacement. Outcomes:. No arrhythmia detected following treatment. Lessons:. Awareness of the association between hypothyroidism and COVID-19 is important in preventing possible complications.