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Plasmonics is a field connected to optics dealing with the properties and applications of surface plasmons which are modes of metal dielectric interfaces. Nanoplasmonics concerns the excitation, manipulation and detection of the surface plasmons at the nanometric scale. It has highly potential applications for ultrasensitive biochemical sensing. Surface enhanced spectroscopies are the ultimate sensor tools as they can reach single molecule sensitivity. We will present in this paper our results towards the realization of highly controllable and reproducible nanoplasmonics substrates.