Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil
oleh: Milena Polotto, Tiago Casella, Fernanda Modesto Tolentino, Mayra Mioto Mataruco, Naiady Konno Madela Porto, Mirella Fontana Batista Binhardi, Mara Corrêa Lelles Nogueira
| Format: | Article |
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| Diterbitkan: | Sociedade Brasileira de Medicina Tropical (SBMT) 2019-12-01 |
Deskripsi
Abstract INTRODUCTION: Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs). METHODS: Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital. RESULTS: The key genes found were bla OXA-51-like, the association ISAba1- bla OXA-23-like, and the AME genes aph(3´)-VI, aac(6´)-Ib, aac(3)-Ia, and aph(3´)-Ia. Different clusters spread through the institution wards. CONCLUSIONS: The dissemination of bla OXA-23-like and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection.