The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS
oleh: Tian-Chen Xiong, Ming-Cong Wei, Fang-Xu Li, Miao Shi, Hu Gan, Zhen Tang, Hong-Peng Dong, Tianzi Liuyu, Pu Gao, Bo Zhong, Zhi-Dong Zhang, Dandan Lin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
The activity and stability of the cytosolic DNA sensor cGAS, a key mediator of innate antiviral immunity and autoimmunity, is fine-tuned by post-translational modifications. Here, the authors demonstrate that the ubiquitin E3 ligase ARIH1 catalyzes the mono-ISGylation of cGAS and promotes its oligomerization in response to viral and self DNA.