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<p>The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used dynamic nuclear polarization (DNP) technique that is already used in clinical trials, the parahydrogen (<span class="inline-formula"><i>p</i></span>H<span class="inline-formula">₂)</span>-based hyperpolarization approaches are less cost-intensive, are scalable, and offer high throughput. However, a <span class="inline-formula"><i>p</i></span>H<span class="inline-formula">₂</span> generator is necessary. Available commercial <span class="inline-formula"><i>p</i></span>H<span class="inline-formula">₂</span> generators are relatively expensive (EUR 10 000–150 000). To facilitate the spread of <span class="inline-formula"><i>p</i></span>H<span class="inline-formula">₂</span>-based hyperpolarization studies, here we provide the blueprints and 3D models as open-source for a low-cost (EUR <span class="inline-formula">&lt;3000</span>) 50-bar liquid-nitrogen-cooled <span class="inline-formula"><i>p</i></span>H<span class="inline-formula">₂</span> generator.</p>