RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment

oleh: Pallabi Basu, Maya Elgrably-Weiss, Fouad Hassouna, Manoj Kumar, Reuven Wiener, Shoshy Altuvia

Format: Article
Diterbitkan: Nature Portfolio 2021-04-01

Deskripsi

RelA stimulates RyhB small RNA–target mRNA interaction by promoting assembly of Hfq monomers into hexamers. Here the authors show that RelA-mediated Hfq hexamerization requires an initial binding of RNA to Hfq monomers.