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Aim. To elaborate additional electrocardiographic (ECG) criteria for evaluation of the thrombolytic therapy (TLT) efficacy  in patients with acute coronary syndrome (ACS) with ST segment elevation with discriminant model construction. Material and methods. TLT with streptokinase was performed in 123 patients (108 men, 15 women) with ACS with ST segment elevation in the first 6 h after symptoms onset. Streptokinase i.v. infusion was performed in dose of 1.5 million IU. ECG was recorded at baseline and after TLT. Results. Additional ECG criteria for evaluation of TLT efficacy was elaborated in patients with ACS with ST segment elevation: sum of ST segment elevations in 12-lead; ratio of registered QT interval duration to proper corrected QT interval; corrected variance. Among 123 patients elaborated model was correct in 92.7% of cases. Conclusion. Elaborated discriminant model provides an opportunity to specify effective, uncertain and ineffective TLT within 3 h after TLT.