Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis
oleh: Jin-Long Gao, Ann H. Kwan, Anthony Yammine, Xiaoyan Zhou, Jill Trewhella, Barbara M. Hugrass, Daniel A. T. Collins, James Horne, Ping Ye, Derek Harty, Ky-Anh Nguyen, David A. Gell, Neil Hunter
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-10-01 |
Deskripsi
The pathogenic bacterium Porphyromonas gingivalis causes periodontal disease and depends on porphyrin from host sources. Here the authors show that the P. gingivalis haem uptake system protein A (HusA) mediates the uptake of exogenous porphyrin, present its solution NMR structure and show how HusA can be exploited as a drug target.