In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits
oleh: Xiangbo Ruan, Ping Li, Yi Chen, Yu Shi, Mehdi Pirooznia, Fayaz Seifuddin, Hiroshi Suemizu, Yasuyuki Ohnishi, Nao Yoneda, Megumi Nishiwaki, James Shepherdson, Abhilash Suresh, Komudi Singh, Yonghe Ma, Cheng-fei Jiang, Haiming Cao
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2020-01-01 |
Deskripsi
Majority of human long non-coding RNAs (lncRNAs) are not conserved in mouse. Here the authors identify metabolic trait-associated lncRNA genes and show a functional role of a non-conserved human lncRNA, LINC01018, in lipid metabolism using a humanized mouse model.