Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p
oleh: Lin Bai, Amanda Kovach, Qinglong You, Hao-Chi Hsu, Gongpu Zhao, Huilin Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-09-01 |
Deskripsi
The heterodimeric eukaryotic Drs2p-Cdc50p complex is a lipid flippase that maintains cell membrane asymmetry and its autoinhibition is released by PI4P binding. Here authors show cryo-EM structures of Drs2p-Cdc50p in apo and PI4P-activated form which reveal the structural changes upon PI4P binding.