Find in Library

Five new diisoprenyl cyclohexene-type meroterpenoids, aspergienynes J–N (<b>1</b>–<b>5</b>), along with three known analogues (<b>6</b>–<b>8</b>), were obtained from the mangrove endophytic fungal strain <i>Aspergillus</i> sp. GXNU-Y85. The chemical structures, including their absolute configurations, were established via spectroscopic data and comparison of experimental and calculated ECD spectra. Cytotoxicity assay results indicated that compound <b>8</b> had strong cytotoxicity against HeLa cancer cells, and its IC₅₀ value was 11.8 μM. In addition, flow cytometry analysis revealed that the cytotoxicity of <b>8</b> was due to the induction of G1 cell cycle arrest and apoptosis in HeLa cells.