Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding
oleh: Yusuke Toyoda, Cedric J. Cattin, Martin P. Stewart, Ina Poser, Mirko Theis, Teymuras V. Kurzchalia, Frank Buchholz, Anthony A. Hyman, Daniel J. Müller
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-11-01 |
Deskripsi
During cell division animal cells generate intracellular pressure and round against their environment, but the genes responsible for this are largely unknown. Here the authors use a microcantilever- and RNAi-based assay to screen > 1000 genes and identify 49 genes involved in mitotic cell rounding; many are novel to this process.