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The aim of this study was determined to check the effect of NIDDM on Amylase Enzyme and amylase creatinine clearance rate. The specimens were collected from 48 patients suffering from Non Insulin Dependant Diabetes Mellitus (23 females,25 males). Amylase tests, creatinine test in serum and urine were done. The results show increased of amylase level in serum, urine amylase and amylase ceratinine clearance rates were (262, 520,7.8) respectively when compared with the control were (140, 313,3.19) respectively.