Various myosteatosis selection criteria and their value in the assessment of short- and long-term outcomes following liver transplantation

oleh: Franziska Alexandra Meister, Jan Bednarsch, Iakovos Amygdalos, Joerg Boecker, Pavel Strnad, Philipp Bruners, Sven Arke Lang, Tom Florian Ulmer, Lara Heij, Daniel Antonio Morales Santana, Wen-Jia Liu, Georg Lurje, Ulf Peter Neumann, Zoltan Czigany

Format: Article
Diterbitkan: Nature Portfolio 2021-06-01

Deskripsi

Abstract Body composition and myosteatosis affect clinical outcomes in orthotopic liver transplantation (OLT). Here we aimed to compare the value and limitations of various selection criteria to define pre-transplant myosteatosis in the assessment of short- and long-term outcomes following OLT. We retrospectively analyzed the data of 264 consecutive recipients who underwent deceased donor OLT at a German university medical centre. Myosteatosis was evaluated by preoperative computed-tomography-based segmentation. Patients were stratified using muscle radiation attenuation of the whole muscle area (L3Muslce-RA), psoas RA (L3Psoas-RA) and intramuscular adipose tissue content (IMAC) values. L3Muslce-RA, L3Psoas-RA and IMAC performed well without major differences and identified patients at risk for inferior outcomes in the group analysis. Quartile-based analyses, receiver operating characteristic curve and correlation analyses showed a superior association of L3Muslce-RA with perioperative outcomes when compared to L3Psoas-RA and L3IMAC. Long-term outcome did not show any major differences between the used selection criteria. This study confirms the prognostic role of myosteatosis in OLT with a particularly strong value in the perioperative phase. Although, based on our data, L3Muscle-RA might be the most suitable and recommended selection criterion to assess CT-based myosteatosis when compared to L3Psoas-RA and L3IMAC, further studies are warranted to validate these findings.