Hepatic HuR modulates lipid homeostasis in response to high-fat diet
oleh: Zhuojun Zhang, Chen Zong, Mingyang Jiang, Han Hu, Xiaolei Cheng, Juhua Ni, Xia Yi, Bin Jiang, Feng Tian, Ming-Wen Chang, Wen Su, Lijun Zhu, Jinfan Li, Xueping Xiang, Congxiu Miao, Myriam Gorospe, Rafael de Cabo, Yali Dou, Zhenyu Ju, Jichun Yang, Changtao Jiang, Zhongzhou Yang, Wengong Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-06-01 |
Deskripsi
Human antigen R (HuR) is a RNA binding protein involved in the regulation of many cellular functions. Here the authors show that, hepatocyte specific deletion of HuR exacerbates high-fat diet-induced NAFLD in mice by regulating transcripts involved in lipid transport and ATP synthesis.