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This report presents the imaging findings in a patient with advanced prostate cancer and bone metastases. A superscan pattern on the initial whole-body bone scan suggested extensive disease. The patient responded well to definitive treatment, exhibiting clinical improvement based on decreased PSA levels and CT findings in 6-month follow-up. However, serial follow-up bone scans showed normalization in about 18 months. This paper aims to discuss the limitations of bone scintigraphy in evaluating treatment responses in patients with prostate cancer.