2-(5-phenyl-4H-1,2,4-triazol-3-ylthio)acetic acid: Greener and efficient organocatalyst for multicomponent reactions under aqueous media

oleh: Harsha Sharma, Sunny Sharma, Satya Paul

Format: Article
Diterbitkan: Elsevier 2021-01-01

Deskripsi

A simple, ecofriendly and competent method is reported for the synthesis of functionalized amines via reductive amination of carbonyl compounds with amines and β-amino ketones via Mannich reaction, using greener and efficient organocatalyst, 2-(5-phenyl-4H-1,2,4-triazol-3-ylthio)acetic acid under microwave radiation. The synthesized organocatalyst is characterized for its structural properties via 1H NMR, 13C NMR, DEPT NMR, Mass spectrum and FTIR Spectrum. Furthermore, an in silico 3D model of the 2-(5-phenyl-4H-1,2,4-triazol-3-ylthio)acetic acid is also deciphered using cheminfo computational tool. The current method affords products in good to excellent yields under moderate reaction conditions. Besides, the catalyst is also recyclable up to 4 runs without a considerable loss in its activity.