TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation
oleh: Jianfang Li, Xinwei Wu, Jie Ke, Minjung Lee, Qingping Lan, Jia Li, Jianxiu Yu, Yun Huang, De-Qiang Sun, Ruiyu Xie
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-07-01 |
Deskripsi
Here the authors show that TET1 is required for the generation of functional insulin-producing cells, FOXA2 physically interacts with TET1 and contributes to specific recruitment of TET1 to mediate chromatin opening at the regulatory elements of pancreatic lineage determinants.