Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
oleh: Oleksandr Frei, Dominic Holland, Olav B. Smeland, Alexey A. Shadrin, Chun Chieh Fan, Steffen Maeland, Kevin S. O’Connell, Yunpeng Wang, Srdjan Djurovic, Wesley K. Thompson, Ole A. Andreassen, Anders M. Dale
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-06-01 |
Deskripsi
To better understand the phenotypic relationships of complex traits it is also important to understand their genetic overlap. Here, Frei et al. develop MiXeR which uses GWAS summary statistics to evaluate the polygenic overlap between two traits irrespective of their genetic correlation.