Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm
oleh: Shelby Kutty, MD, PhD, MHCM, Na Liu, MD, PhD, Jia Zhou, MD, PhD, Yunbin Xiao, MD, PhD, Juefei Wu, MD, PhD, David A. Danford, MD, John Lof, MS, Feng Xie, MD, Thomas R. Porter, MD
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2017-12-01 |
Deskripsi
Inertial cavitation inducing ultrasound-mediated microbubble treatments can produce resolution of vasospasm and restoration of distal arterial flow after peripheral artery injury. Resolution of catheter-induced vasospasm is likely to be nitric oxide- mediated because improvements in stenosis diameter and downstream blood flow were blunted following pretreatment with L-NAME. The potential for clinical applicability of this therapy is significant because: 1) microbubbles can be delivered systemically into the site of injury enabling relatively high local concentration; 2) targeted transcutaneous ultrasound delivery is achievable due to the proximity of vessels; and 3) microbubbles and diagnostic ultrasound system used are commercially available.